Acta Pharm. 52 (2002) 123-130

Development and in-vitro evaluation of novel buccoadhesive
tablet formulation of prednisolone

MORTEZA RAFIEE-TEHRANI,^1* GHIASSEDIN JAZAYERI,¹ TAYEBEH TOLIYAT,¹  KHOSSROW BAYATI,² KAZEM KHALKHALI,² KOUROSH SHAMIMI,²  ASGHAR MIREMADI² 
and FARID A. DORKOOSH³

rafitehr@ams.ac.ir

¹School of Pharmacy, Tehran University of Medical Sciences, Tehran 14, Iran
²School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
³LACDR, Leiden University, Leiden, The Netherlands

Buccoadhesive tablets for the treatment of aphtha were prepared by mixing prednisolone with various amounts of different polymers. The adhesion of each formulation was measured as well as the release of the drug from buccoadhesive tablets. The increasing concentrations of Polycarbophil (PCP) and Carbopol 934p (CP) caused higher adhesive properties of the prepared formulations. However, adhesion force did not change upon increasing the concentration of sodium carboxymethyl cellulose (CMC) in the formulations. Increasing of hydroxypropylmethyl cellulose (SCMC) concentration in the formulations containing CP and PCP caused a downward shift in viscosities. However, the viscosity of the formulation fabricated with CMC was not affected by HPMC concentration. Buccoadhesive tablets containing a combination of 5% CP, 10% PCP and 10% HPMC demonstrated a pronounced and significant sigmoidal release after a logical lag time.

Keywords: prednisolone, buccoadhesive tablet, in-vitro release, Carbopol, Polycarbophil

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