Acta Pharm. 52 (2002) 131-138

Synthesis and antiviral activity of quinazolyl thiatriazoles

VINOD KUMAR PANDEY,^1* ZEHRA TUSI,¹  SARAH TUSI, ¹ MADHAWANAND JOSHI²  and SHASHIKALA BAJPAI²

vkpandey48@yahoo.com

¹Department of Chemistry, University of Lucknow, Lucknow (U.P.) - 226 007, India
²Division of Microbiology, Central Drug Research Institute, Lucknow (U.P.) - 226 001, India

5-Arylamido/imido-alkyl-2-aminobenzoic acids (1) were prepared by condensing 2-aminobenzoic acid with amido/imido alcohols. Reaction of 1 with benzoyl chloride in pyridine afforded 2-phenyl-6-arylamido/imido-alkyl-3,4-dihydrobenzoxazine-4-ones (2). Interaction of 2 with thiosemicarbazide in ethanol resulted in 2-phenyl-6-arylamido/imido-alkyl-3-thiatriazolo [1,5-c] (3H) quinazolines (3). Antiviral activity of the latter compounds was evaluated upon Japanese encephalitis virus (JEV) and Herpes simplex virus-1 (HSV-1) activity on vero cells in vitro.

Keywords: quinazolyl thiatriazoles, synthesis, antiviral activity, immuno-stimulation, haemagglutination, cytotoxicity

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