Acta Pharm. 48 (1998) 55-61

Synthesis and biological screening of 3,5-dinitrobenzoyl-4-aminobenzamidomethyl sulfonamides

NAVITA KHOSLA   and   SHEELA JOSHI^*

Institute of Chemical Sciences, Devi Ahilya Vishwavidyalaya Khandwa Road,
Indore-452001 India

Biologically active Mannich bases with nitro substituted aromatic ring system have been synthesized by Mannich reaction of substituted dinitrobenzamide with various sulfonamides. They were characterized by elemental analysis, UV, IR and ¹H NMR studies, and screened for toxicity and antibacterial activity against various pathogenic bacteria at varying concentrations. The compounds showed strong antibacterial activity and were found to be markedly superior to corresponding sulfonamides. All the compounds were found to be of low toxicity as ascertained by LD₅₀ test.

Keywords: Mannich bases, sulfonamides, LD₅₀ test

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